Prevention of lymphocele by using gelatin-thrombin matrix as a tissue sealant after pelvic lymphadenectomy in patients with gynecologic cancers: a prospective randomized controlled study
Identifieur interne : 000271 ( Main/Exploration ); précédent : 000270; suivant : 000272Prevention of lymphocele by using gelatin-thrombin matrix as a tissue sealant after pelvic lymphadenectomy in patients with gynecologic cancers: a prospective randomized controlled study
Auteurs : Yun Hwan Kim ; Hyun Joo Shin ; Woong Ju ; Seung-Cheol KimSource :
- Journal of Gynecologic Oncology [ 2005-0380 ] ; 2017.
Abstract
This prospective randomized controlled pilot study aimed to find whether gelatin-thrombin matrix used as a tissue sealant (FloSeal) can prevent the occurrence of pelvic lymphocele in patients with gynecologic cancer who has undergone pelvic lymphadenectomy.
Each patient, who undergo a laparotomic pelvic lymph node dissection on both sides, was randomly assigned for FloSeal application on 1 side of the pelvis. The other side of the pelvis without any product application being the control side. The amount of lymph drainage at each side of the pelvis was measured for 3 days, and computed tomography scans were obtained 7 days and 6 months after surgery for detection of pelvic lymphocele.
Among 37 cases, the median amount of lymph drainage was significantly decreased in the hemi-pelvis treated with FloSeal compared to the control hemi-pelvis (p=0.025). The occurrence of lymphocele was considerably reduced in treated hemi-pelvis (8/37, 21.6%) compared with control hemi-pelvis (12/37, 32.4%) after 7 post-operative days (p=0.219), and more decreased in the treated hemi-pelvis (5/37, 13.5%) compared with control hemi-pelvis (9/37, 24.3%) after postoperative 6 months (p=0.344).
The application of FloSeal as a tissue sealant in lymph nodes resected tissues can reduce the incidence of pelvic lymphocele in gynecologic cancer patients. A large randomized controlled study could confirm these preliminary results.
Url:
DOI: 10.3802/jgo.2017.28.e37
PubMed: 28382800
PubMed Central: 5391396
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Prevention of lymphocele by using gelatin-thrombin matrix as a tissue sealant after pelvic lymphadenectomy in patients with gynecologic cancers: a prospective randomized controlled study</title><author><name sortKey="Kim, Yun Hwan" sort="Kim, Yun Hwan" uniqKey="Kim Y" first="Yun Hwan" last="Kim">Yun Hwan Kim</name><affiliation><nlm:aff id="A1"></nlm:aff></affiliation></author><author><name sortKey="Shin, Hyun Joo" sort="Shin, Hyun Joo" uniqKey="Shin H" first="Hyun Joo" last="Shin">Hyun Joo Shin</name><affiliation><nlm:aff id="A1"></nlm:aff></affiliation></author><author><name sortKey="Ju, Woong" sort="Ju, Woong" uniqKey="Ju W" first="Woong" last="Ju">Woong Ju</name><affiliation><nlm:aff id="A1"></nlm:aff></affiliation></author><author><name sortKey="Kim, Seung Cheol" sort="Kim, Seung Cheol" uniqKey="Kim S" first="Seung-Cheol" last="Kim">Seung-Cheol Kim</name><affiliation><nlm:aff id="A1"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">28382800</idno><idno type="pmc">5391396</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5391396</idno><idno type="RBID">PMC:5391396</idno><idno type="doi">10.3802/jgo.2017.28.e37</idno><date when="2017">2017</date><idno type="wicri:Area/Pmc/Corpus">004076</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">004076</idno><idno type="wicri:Area/Pmc/Curation">004075</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">004075</idno><idno type="wicri:Area/Pmc/Checkpoint">000128</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000128</idno><idno type="wicri:Area/Ncbi/Merge">008F49</idno><idno type="wicri:Area/Ncbi/Curation">008F49</idno><idno type="wicri:Area/Ncbi/Checkpoint">008F49</idno><idno type="wicri:doubleKey">2005-0380:2017:Kim Y:prevention:of:lymphocele</idno><idno type="wicri:Area/Main/Merge">000271</idno><idno type="wicri:Area/Main/Curation">000271</idno><idno type="wicri:Area/Main/Exploration">000271</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Prevention of lymphocele by using gelatin-thrombin matrix as a tissue sealant after pelvic lymphadenectomy in patients with gynecologic cancers: a prospective randomized controlled study</title><author><name sortKey="Kim, Yun Hwan" sort="Kim, Yun Hwan" uniqKey="Kim Y" first="Yun Hwan" last="Kim">Yun Hwan Kim</name><affiliation><nlm:aff id="A1"></nlm:aff></affiliation></author><author><name sortKey="Shin, Hyun Joo" sort="Shin, Hyun Joo" uniqKey="Shin H" first="Hyun Joo" last="Shin">Hyun Joo Shin</name><affiliation><nlm:aff id="A1"></nlm:aff></affiliation></author><author><name sortKey="Ju, Woong" sort="Ju, Woong" uniqKey="Ju W" first="Woong" last="Ju">Woong Ju</name><affiliation><nlm:aff id="A1"></nlm:aff></affiliation></author><author><name sortKey="Kim, Seung Cheol" sort="Kim, Seung Cheol" uniqKey="Kim S" first="Seung-Cheol" last="Kim">Seung-Cheol Kim</name><affiliation><nlm:aff id="A1"></nlm:aff></affiliation></author></analytic><series><title level="j">Journal of Gynecologic Oncology</title><idno type="ISSN">2005-0380</idno><idno type="eISSN">2005-0399</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Objective</title><p>This prospective randomized controlled pilot study aimed to find whether gelatin-thrombin matrix used as a tissue sealant (FloSeal) can prevent the occurrence of pelvic lymphocele in patients with gynecologic cancer who has undergone pelvic lymphadenectomy.</p></sec><sec><title>Methods</title><p>Each patient, who undergo a laparotomic pelvic lymph node dissection on both sides, was randomly assigned for FloSeal application on 1 side of the pelvis. The other side of the pelvis without any product application being the control side. The amount of lymph drainage at each side of the pelvis was measured for 3 days, and computed tomography scans were obtained 7 days and 6 months after surgery for detection of pelvic lymphocele.</p></sec><sec><title>Results</title><p>Among 37 cases, the median amount of lymph drainage was significantly decreased in the hemi-pelvis treated with FloSeal compared to the control hemi-pelvis (p=0.025). The occurrence of lymphocele was considerably reduced in treated hemi-pelvis (8/37, 21.6%) compared with control hemi-pelvis (12/37, 32.4%) after 7 post-operative days (p=0.219), and more decreased in the treated hemi-pelvis (5/37, 13.5%) compared with control hemi-pelvis (9/37, 24.3%) after postoperative 6 months (p=0.344).</p></sec><sec><title>Conclusion</title><p>The application of FloSeal as a tissue sealant in lymph nodes resected tissues can reduce the incidence of pelvic lymphocele in gynecologic cancer patients. 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Kw" uniqKey="Lam K">KW Lam</name></author><author><name sortKey="Chan, Kk" uniqKey="Chan K">KK Chan</name></author><author><name sortKey="Ngan, Hy" uniqKey="Ngan H">HY Ngan</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="Ju, Woong" sort="Ju, Woong" uniqKey="Ju W" first="Woong" last="Ju">Woong Ju</name><name sortKey="Kim, Seung Cheol" sort="Kim, Seung Cheol" uniqKey="Kim S" first="Seung-Cheol" last="Kim">Seung-Cheol Kim</name><name sortKey="Kim, Yun Hwan" sort="Kim, Yun Hwan" uniqKey="Kim Y" first="Yun Hwan" last="Kim">Yun Hwan Kim</name><name sortKey="Shin, Hyun Joo" sort="Shin, Hyun Joo" uniqKey="Shin H" first="Hyun Joo" last="Shin">Hyun Joo Shin</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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